DIM, or diindolylmethane, is known for the role it plays in stimulating natural detoxification enzymes and supporting normal estrogen metabolism. As a natural component metabolized from indole-3-carbinole and cruciferous vegetables, DIM has shown in studies to support the formation of 2-hydroxylation instead of 16-hydroxylation of certain estrogen metabolites. This favors the production of 2-hydroxysterone over the less desirable 16-hydroxyestrone. Other studies indicate that diindolylmethane may play important roles in inducing apoptosis and supporting the body’s normal angiogenic balance, especially in regards to healthy breast, cervical and prostate cells.
The use of hormone replacement therapy, especially in women during menopause and perimenopause is quite popular these days. Combing DIM with HRT may better promote estrogen metabolism and support healthy estrogen levels, since low estrogen can lead to hot flashes, night sweats, and mood changes. DIM in combination why phytoestrogens from plants can provide independent and similar actions to support women’s health. Phytoestrogens such as the isoflavone genistein mimic estrogen-like activity, unlike DIM, and positively influence bone mineral metabolism and protect blood proteins from oxidation.
DIM can also help to maintain a healthy balance between estrogen and free testosterone by reducing elevated levels of SHBG. Higher ratios of testosterone to estrogen have been linked to lower body fat mass and fat-burning metabolism, in addition to improved mood and libido.
About Dr. Shel
Known as “Dr. Shel”, she is the founder and medical director of the Dr. Shel Wellness & Medical Spa in Sugar Land, Texas. An honor graduate of Emory University School of Medicine, and a Board Certified Obstetrician and Gynecologist. Dr. Shel is a Douglas Laboratories Clinical Advisor.